0.1.1 - ci-build
ScheduleOfActivityIG - Local Development build (v0.1.1). See the Directory of published versions
@prefix fhir: <http://hl7.org/fhir/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
# - resource -------------------------------------------------------------------
a fhir:Group;
fhir:nodeRole fhir:treeRoot;
fhir:Resource.id [ fhir:value "H2Q-MC-LZZT-ResearchStudy-Exclusion"];
fhir:DomainResource.text [
fhir:Narrative.status [ fhir:value "generated" ];
fhir:Narrative.div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative</b></p><p><b>type</b>: person</p><p><b>actual</b>: false</p><blockquote><p><b>characteristic</b></p><p><b>code</b>: <span title=\"Codes: \">Persons who have previously completed or withdrawn from this study or any other study investigating xanomeline TTS or the oral formulation of xanomeline.</span></p><p><b>value</b>: true</p><p><b>exclude</b>: true</p></blockquote><blockquote><p><b>characteristic</b></p><p><b>code</b>: <span title=\"Codes: \">Use of any investigational agent or approved Alzheimer’s therapeutic medication within 30 days prior to enrollment into the study.</span></p><p><b>value</b>: true</p><p><b>exclude</b>: true</p></blockquote><blockquote><p><b>characteristic</b></p><p><b>code</b>: <span title=\"Codes: \">Serious illness which required hospitalization within 3 months of screening.</span></p><p><b>value</b>: true</p><p><b>exclude</b>: true</p></blockquote><blockquote><p><b>characteristic</b></p><p><b>code</b>: <span title=\"Codes: \">Stroke or vascular dementia documented by clinical history and/or radiographic findings interpretable by the investigator as indicative of these disorders</span></p><p><b>value</b>: true</p><p><b>exclude</b>: true</p></blockquote><blockquote><p><b>characteristic</b></p><p><b>code</b>: <span title=\"Codes: \">Seizure disorder other than simple childhood febrile seizures</span></p><p><b>value</b>: true</p><p><b>exclude</b>: true</p></blockquote><blockquote><p><b>characteristic</b></p><p><b>code</b>: <span title=\"Codes: \">Severe head trauma resulting in protracted loss of consciousness within the last 5 years, or multiple episodes of head trauma</span></p><p><b>value</b>: true</p><p><b>exclude</b>: true</p></blockquote><blockquote><p><b>characteristic</b></p><p><b>code</b>: <span title=\"Codes: \">Parkinson’s disease</span></p><p><b>value</b>: true</p><p><b>exclude</b>: true</p></blockquote><blockquote><p><b>characteristic</b></p><p><b>code</b>: <span title=\"Codes: \">Multiple sclerosis</span></p><p><b>value</b>: true</p><p><b>exclude</b>: true</p></blockquote><blockquote><p><b>characteristic</b></p><p><b>code</b>: <span title=\"Codes: \">Amyotrophic lateral sclerosis</span></p><p><b>value</b>: true</p><p><b>exclude</b>: true</p></blockquote><blockquote><p><b>characteristic</b></p><p><b>code</b>: <span title=\"Codes: \">Myasthenia gravis</span></p><p><b>value</b>: true</p><p><b>exclude</b>: true</p></blockquote><blockquote><p><b>characteristic</b></p><p><b>code</b>: <span title=\"Codes: \">Episode of depression meeting DSM-IV criteria within 3 months of screening.</span></p><p><b>value</b>: true</p><p><b>exclude</b>: true</p></blockquote><blockquote><p><b>characteristic</b></p><p><b>code</b>: <span title=\"Codes: \">A history within the last 5 years of Schizophrenia.</span></p><p><b>value</b>: true</p><p><b>exclude</b>: true</p></blockquote><blockquote><p><b>characteristic</b></p><p><b>code</b>: <span title=\"Codes: \">A history within the last 5 years of Bipolar Disease.</span></p><p><b>value</b>: true</p><p><b>exclude</b>: true</p></blockquote><blockquote><p><b>characteristic</b></p><p><b>code</b>: <span title=\"Codes: \">A history within the last 5 years of Ethanol or psychoactive drug abuse or dependence.</span></p><p><b>value</b>: true</p><p><b>exclude</b>: true</p></blockquote><blockquote><p><b>characteristic</b></p><p><b>code</b>: <span title=\"Codes: \">A history of syncope within the last 5 years.</span></p><p><b>value</b>: true</p><p><b>exclude</b>: true</p></blockquote><blockquote><p><b>characteristic</b></p><p><b>code</b>: <span title=\"Codes: \">Evidence from ECG recording of Left bundle branch block.</span></p><p><b>value</b>: true</p><p><b>exclude</b>: true</p></blockquote><blockquote><p><b>characteristic</b></p><p><b>code</b>: <span title=\"Codes: \">Evidence from ECG recording of Bradycardia ≤50 beats per minute</span></p><p><b>value</b>: true</p><p><b>exclude</b>: true</p></blockquote><blockquote><p><b>characteristic</b></p><p><b>code</b>: <span title=\"Codes: \">Evidence from ECG recording of Sinus pauses >2 seconds</span></p><p><b>value</b>: true</p><p><b>exclude</b>: true</p></blockquote><blockquote><p><b>characteristic</b></p><p><b>code</b>: <span title=\"Codes: \">Evidence from ECG recording of Second or third degree heart block unless treated with a pacemaker</span></p><p><b>value</b>: true</p><p><b>exclude</b>: true</p></blockquote><blockquote><p><b>characteristic</b></p><p><b>code</b>: <span title=\"Codes: \">Evidence from ECG recording of Wolff-Parkinson-White syndrome</span></p><p><b>value</b>: true</p><p><b>exclude</b>: true</p></blockquote><blockquote><p><b>characteristic</b></p><p><b>code</b>: <span title=\"Codes: \">Evidence from ECG recording of Sustained supraventricular tachyarrhythmia including SVT≥10 sec, atrial fibrillation, atrial flutter.</span></p><p><b>value</b>: true</p><p><b>exclude</b>: true</p></blockquote><blockquote><p><b>characteristic</b></p><p><b>code</b>: <span title=\"Codes: \">Evidence from ECG recording of Ventricular tachycardia at a rate of ≥120 beats per minute lasting ≥10 seconds.</span></p><p><b>value</b>: true</p><p><b>exclude</b>: true</p></blockquote><blockquote><p><b>characteristic</b></p><p><b>code</b>: <span title=\"Codes: \">A history within the last 5 years of Clinically significant arrhythmia</span></p><p><b>value</b>: true</p><p><b>exclude</b>: true</p></blockquote><blockquote><p><b>characteristic</b></p><p><b>code</b>: <span title=\"Codes: \">A history within the last 5 years of Symptomatic sick sinus syndrome not treated with a pacemaker</span></p><p><b>value</b>: true</p><p><b>exclude</b>: true</p></blockquote><blockquote><p><b>characteristic</b></p><p><b>code</b>: <span title=\"Codes: \">A history within the last 5 years of Congestive heart failure refractory to treatment</span></p><p><b>value</b>: true</p><p><b>exclude</b>: true</p></blockquote><blockquote><p><b>characteristic</b></p><p><b>code</b>: <span title=\"Codes: \">A history within the last 5 years of Angina except angina controlled with PRN nitroglycerin</span></p><p><b>value</b>: true</p><p><b>exclude</b>: true</p></blockquote><blockquote><p><b>characteristic</b></p><p><b>code</b>: <span title=\"Codes: \">A history within the last 5 years of Resting heart rate <50 or >100 beats per minute, on physical exam</span></p><p><b>value</b>: true</p><p><b>exclude</b>: true</p></blockquote><blockquote><p><b>characteristic</b></p><p><b>code</b>: <span title=\"Codes: \">A history within the last 5 years of Uncontrolled hypertension.</span></p><p><b>value</b>: true</p><p><b>exclude</b>: true</p></blockquote><blockquote><p><b>characteristic</b></p><p><b>code</b>: <span title=\"Codes: \">A history within the last 5 years of a serious gastrointestinal disorder</span></p><p><b>value</b>: true</p><p><b>exclude</b>: true</p></blockquote></div>"
];
fhir:Group.type [ fhir:value "person"];
fhir:Group.actual [ fhir:value "false"^^xsd:boolean];
fhir:Group.characteristic [
fhir:index 0;
fhir:Group.characteristic.code [
fhir:CodeableConcept.text [ fhir:value "Persons who have previously completed or withdrawn from this study or any other study investigating xanomeline TTS or the oral formulation of xanomeline." ] ];
fhir:Group.characteristic.valueBoolean [ fhir:value "true"^^xsd:boolean ];
fhir:Group.characteristic.exclude [ fhir:value "true"^^xsd:boolean ]
], [
fhir:index 1;
fhir:Group.characteristic.code [
fhir:CodeableConcept.text [ fhir:value "Use of any investigational agent or approved Alzheimer’s therapeutic medication within 30 days prior to enrollment into the study." ] ];
fhir:Group.characteristic.valueBoolean [ fhir:value "true"^^xsd:boolean ];
fhir:Group.characteristic.exclude [ fhir:value "true"^^xsd:boolean ]
], [
fhir:index 2;
fhir:Group.characteristic.code [
fhir:CodeableConcept.text [ fhir:value "Serious illness which required hospitalization within 3 months of screening." ] ];
fhir:Group.characteristic.valueBoolean [ fhir:value "true"^^xsd:boolean ];
fhir:Group.characteristic.exclude [ fhir:value "true"^^xsd:boolean ]
], [
fhir:index 3;
fhir:Group.characteristic.code [
fhir:CodeableConcept.text [ fhir:value "Stroke or vascular dementia documented by clinical history and/or radiographic findings interpretable by the investigator as indicative of these disorders" ] ];
fhir:Group.characteristic.valueBoolean [ fhir:value "true"^^xsd:boolean ];
fhir:Group.characteristic.exclude [ fhir:value "true"^^xsd:boolean ]
], [
fhir:index 4;
fhir:Group.characteristic.code [
fhir:CodeableConcept.text [ fhir:value "Seizure disorder other than simple childhood febrile seizures" ] ];
fhir:Group.characteristic.valueBoolean [ fhir:value "true"^^xsd:boolean ];
fhir:Group.characteristic.exclude [ fhir:value "true"^^xsd:boolean ]
], [
fhir:index 5;
fhir:Group.characteristic.code [
fhir:CodeableConcept.text [ fhir:value "Severe head trauma resulting in protracted loss of consciousness within the last 5 years, or multiple episodes of head trauma" ] ];
fhir:Group.characteristic.valueBoolean [ fhir:value "true"^^xsd:boolean ];
fhir:Group.characteristic.exclude [ fhir:value "true"^^xsd:boolean ]
], [
fhir:index 6;
fhir:Group.characteristic.code [
fhir:CodeableConcept.text [ fhir:value "Parkinson’s disease" ] ];
fhir:Group.characteristic.valueBoolean [ fhir:value "true"^^xsd:boolean ];
fhir:Group.characteristic.exclude [ fhir:value "true"^^xsd:boolean ]
], [
fhir:index 7;
fhir:Group.characteristic.code [
fhir:CodeableConcept.text [ fhir:value "Multiple sclerosis" ] ];
fhir:Group.characteristic.valueBoolean [ fhir:value "true"^^xsd:boolean ];
fhir:Group.characteristic.exclude [ fhir:value "true"^^xsd:boolean ]
], [
fhir:index 8;
fhir:Group.characteristic.code [
fhir:CodeableConcept.text [ fhir:value "Amyotrophic lateral sclerosis" ] ];
fhir:Group.characteristic.valueBoolean [ fhir:value "true"^^xsd:boolean ];
fhir:Group.characteristic.exclude [ fhir:value "true"^^xsd:boolean ]
], [
fhir:index 9;
fhir:Group.characteristic.code [
fhir:CodeableConcept.text [ fhir:value "Myasthenia gravis" ] ];
fhir:Group.characteristic.valueBoolean [ fhir:value "true"^^xsd:boolean ];
fhir:Group.characteristic.exclude [ fhir:value "true"^^xsd:boolean ]
], [
fhir:index 10;
fhir:Group.characteristic.code [
fhir:CodeableConcept.text [ fhir:value "Episode of depression meeting DSM-IV criteria within 3 months of screening." ] ];
fhir:Group.characteristic.valueBoolean [ fhir:value "true"^^xsd:boolean ];
fhir:Group.characteristic.exclude [ fhir:value "true"^^xsd:boolean ]
], [
fhir:index 11;
fhir:Group.characteristic.code [
fhir:CodeableConcept.text [ fhir:value "A history within the last 5 years of Schizophrenia." ] ];
fhir:Group.characteristic.valueBoolean [ fhir:value "true"^^xsd:boolean ];
fhir:Group.characteristic.exclude [ fhir:value "true"^^xsd:boolean ]
], [
fhir:index 12;
fhir:Group.characteristic.code [
fhir:CodeableConcept.text [ fhir:value "A history within the last 5 years of Bipolar Disease." ] ];
fhir:Group.characteristic.valueBoolean [ fhir:value "true"^^xsd:boolean ];
fhir:Group.characteristic.exclude [ fhir:value "true"^^xsd:boolean ]
], [
fhir:index 13;
fhir:Group.characteristic.code [
fhir:CodeableConcept.text [ fhir:value "A history within the last 5 years of Ethanol or psychoactive drug abuse or dependence." ] ];
fhir:Group.characteristic.valueBoolean [ fhir:value "true"^^xsd:boolean ];
fhir:Group.characteristic.exclude [ fhir:value "true"^^xsd:boolean ]
], [
fhir:index 14;
fhir:Group.characteristic.code [
fhir:CodeableConcept.text [ fhir:value "A history of syncope within the last 5 years." ] ];
fhir:Group.characteristic.valueBoolean [ fhir:value "true"^^xsd:boolean ];
fhir:Group.characteristic.exclude [ fhir:value "true"^^xsd:boolean ]
], [
fhir:index 15;
fhir:Group.characteristic.code [
fhir:CodeableConcept.text [ fhir:value "Evidence from ECG recording of Left bundle branch block." ] ];
fhir:Group.characteristic.valueBoolean [ fhir:value "true"^^xsd:boolean ];
fhir:Group.characteristic.exclude [ fhir:value "true"^^xsd:boolean ]
], [
fhir:index 16;
fhir:Group.characteristic.code [
fhir:CodeableConcept.text [ fhir:value "Evidence from ECG recording of Bradycardia ≤50 beats per minute" ] ];
fhir:Group.characteristic.valueBoolean [ fhir:value "true"^^xsd:boolean ];
fhir:Group.characteristic.exclude [ fhir:value "true"^^xsd:boolean ]
], [
fhir:index 17;
fhir:Group.characteristic.code [
fhir:CodeableConcept.text [ fhir:value "Evidence from ECG recording of Sinus pauses >2 seconds" ] ];
fhir:Group.characteristic.valueBoolean [ fhir:value "true"^^xsd:boolean ];
fhir:Group.characteristic.exclude [ fhir:value "true"^^xsd:boolean ]
], [
fhir:index 18;
fhir:Group.characteristic.code [
fhir:CodeableConcept.text [ fhir:value "Evidence from ECG recording of Second or third degree heart block unless treated with a pacemaker" ] ];
fhir:Group.characteristic.valueBoolean [ fhir:value "true"^^xsd:boolean ];
fhir:Group.characteristic.exclude [ fhir:value "true"^^xsd:boolean ]
], [
fhir:index 19;
fhir:Group.characteristic.code [
fhir:CodeableConcept.text [ fhir:value "Evidence from ECG recording of Wolff-Parkinson-White syndrome" ] ];
fhir:Group.characteristic.valueBoolean [ fhir:value "true"^^xsd:boolean ];
fhir:Group.characteristic.exclude [ fhir:value "true"^^xsd:boolean ]
], [
fhir:index 20;
fhir:Group.characteristic.code [
fhir:CodeableConcept.text [ fhir:value "Evidence from ECG recording of Sustained supraventricular tachyarrhythmia including SVT≥10 sec, atrial fibrillation, atrial flutter." ] ];
fhir:Group.characteristic.valueBoolean [ fhir:value "true"^^xsd:boolean ];
fhir:Group.characteristic.exclude [ fhir:value "true"^^xsd:boolean ]
], [
fhir:index 21;
fhir:Group.characteristic.code [
fhir:CodeableConcept.text [ fhir:value "Evidence from ECG recording of Ventricular tachycardia at a rate of ≥120 beats per minute lasting ≥10 seconds." ] ];
fhir:Group.characteristic.valueBoolean [ fhir:value "true"^^xsd:boolean ];
fhir:Group.characteristic.exclude [ fhir:value "true"^^xsd:boolean ]
], [
fhir:index 22;
fhir:Group.characteristic.code [
fhir:CodeableConcept.text [ fhir:value "A history within the last 5 years of Clinically significant arrhythmia" ] ];
fhir:Group.characteristic.valueBoolean [ fhir:value "true"^^xsd:boolean ];
fhir:Group.characteristic.exclude [ fhir:value "true"^^xsd:boolean ]
], [
fhir:index 23;
fhir:Group.characteristic.code [
fhir:CodeableConcept.text [ fhir:value "A history within the last 5 years of Symptomatic sick sinus syndrome not treated with a pacemaker" ] ];
fhir:Group.characteristic.valueBoolean [ fhir:value "true"^^xsd:boolean ];
fhir:Group.characteristic.exclude [ fhir:value "true"^^xsd:boolean ]
], [
fhir:index 24;
fhir:Group.characteristic.code [
fhir:CodeableConcept.text [ fhir:value "A history within the last 5 years of Congestive heart failure refractory to treatment" ] ];
fhir:Group.characteristic.valueBoolean [ fhir:value "true"^^xsd:boolean ];
fhir:Group.characteristic.exclude [ fhir:value "true"^^xsd:boolean ]
], [
fhir:index 25;
fhir:Group.characteristic.code [
fhir:CodeableConcept.text [ fhir:value "A history within the last 5 years of Angina except angina controlled with PRN nitroglycerin" ] ];
fhir:Group.characteristic.valueBoolean [ fhir:value "true"^^xsd:boolean ];
fhir:Group.characteristic.exclude [ fhir:value "true"^^xsd:boolean ]
], [
fhir:index 26;
fhir:Group.characteristic.code [
fhir:CodeableConcept.text [ fhir:value "A history within the last 5 years of Resting heart rate <50 or >100 beats per minute, on physical exam" ] ];
fhir:Group.characteristic.valueBoolean [ fhir:value "true"^^xsd:boolean ];
fhir:Group.characteristic.exclude [ fhir:value "true"^^xsd:boolean ]
], [
fhir:index 27;
fhir:Group.characteristic.code [
fhir:CodeableConcept.text [ fhir:value "A history within the last 5 years of Uncontrolled hypertension." ] ];
fhir:Group.characteristic.valueBoolean [ fhir:value "true"^^xsd:boolean ];
fhir:Group.characteristic.exclude [ fhir:value "true"^^xsd:boolean ]
], [
fhir:index 28;
fhir:Group.characteristic.code [
fhir:CodeableConcept.text [ fhir:value "A history within the last 5 years of a serious gastrointestinal disorder" ] ];
fhir:Group.characteristic.valueBoolean [ fhir:value "true"^^xsd:boolean ];
fhir:Group.characteristic.exclude [ fhir:value "true"^^xsd:boolean ]
].
# - ontology header ------------------------------------------------------------
a owl:Ontology;
owl:imports fhir:fhir.ttl.